2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W017163S
    7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9) 98%
    7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9) is the 13C and 15N labeled 7-Methylxanthine. 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi.
    7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9)
  • HY-W017370R
    Carveol (Standard) 99-48-9
    Carveol (Standard) is the analytical standard of Carveol. This product is intended for research and analytical applications. Carveol is an endogenous metabolite.
    Carveol (Standard)
  • HY-W017443R
    L-Asparagine monohydrate (Standard) 5794-13-8 98%
    L-Asparagine monohydrate (Standard) is the analytical standard of L-Asparagine monohydrate (HY-W017443). This product is intended for research and analytical applications. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine monohydrate (Standard)
  • HY-W017540S
    Cyclocreatine-13C3 98%
    Cyclocreatine-13C3 is the 13C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer.
    Cyclocreatine-13C3
  • HY-W017613R
    (Ethoxymethyl)benzene (Standard) 539-30-0 98%
    (Ethoxymethyl)benzene (Standard) is the analytical standard of (Ethoxymethyl)benzene. This product is intended for research and analytical applications. (Ethoxymethyl)benzene is an endogenous metabolite.
    (Ethoxymethyl)benzene (Standard)
  • HY-W017960R
    Diludine (Standard) 1149-23-1 98%
    Diludine (Standard) is the analytical standard of Diludine (HY-W017960). This product is intended for research and analytical applications. Diludine (BNP-7787) is an orally effective feed additive. Diludine reduces the activity of G6PD and increases the level of superoxide dismutase (SOD). Diludine reduces the mutagenic effect of environmental pollutants, protects parental reproductive systems and improves offspring quality. Diludine is mainly applied during the transition period of dairy cows to increase milk yield and milk fat content, and improve health status during parturition. Diludine can be used in animal feeding research.
    Diludine (Standard)
  • HY-W018161S
    Hexadecanedioic acid-d28 130348-90-2 99.21%
    Hexadecanedioic acid-d28 is the deuterium labeled Hexadecanedioic acid (HY-W018161). Hexadecanedioic acid (Thapsic acid) is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the Nrf2/SLC7A11/GPX4 pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease.
    Hexadecanedioic acid-d28
  • HY-W018197R
    2-Phenylacetamide (Standard) 103-81-1 98%
    2-Phenylacetamide (Standard) is the analytical standard of 2-Phenylacetamide. This product is intended for research and analytical applications. 2-Phenylacetamide is a estrogen-like compound that can be isolated from Lepidium apetalum seeds. 2-Phenylacetamide inhibits p38 MAPK signaling pathway, exhibits anti-inflammatory, antioxidant, anti-hypertensive, and anti-fibrosis effects. 2-Phenylacetamide is orally active.
    2-Phenylacetamide (Standard)
  • HY-W018392R
    Mono-(2-ethylhexyl) phthalate (Standard) 4376-20-9
    Mono-(2-ethylhexyl) phthalate (Standard) is the analytical standard of Mono-(2-ethylhexyl) phthalate. This product is intended for research and analytical applications. Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD).
    Mono-(2-ethylhexyl) phthalate (Standard)
  • HY-W018653R
    Cyclohexaneacetic acid (Standard) 5292-21-7 98%
    Cyclohexaneacetic acid (Standard) is the analytical standard of Naloxone. This product is intended for research and analytical applications. Cyclohexaneacetic acid is recognized as an intermediate of the metabolism of n-alkylcyclohexanes (nACH) in microorganisms. Cyclohexaneacetic acid can be transformed to monohydroxycyclohexaneacetic acids in two Chlorella pyrenoidosa strains.
    Cyclohexaneacetic acid (Standard)
  • HY-W020215R
    Tricarballylic acid (Standard) 99-14-9
    Tricarballylic acid (Standard) is the analytical standard of Tricarballylic acid (HY-W020215). This product is intended for research and analytical applications. Tricarballylic acid is an orally active compound that can be produced by rumen microorganisms and has the activity of chelating magnesium. Tricarballylic acid is also a competitive inhibitor of aconitate hydratase, with a Ki value of 0.52 mM. Tricarballylic acid can inhibit the oxidation of acetate in the citric acid cycle and can be used in the research of ruminant tissue metabolism and grass tetany syndrome. In addition, Tricarballylic acid can be used to synthesize specific complexes and produce plasticizers.
    Tricarballylic acid (Standard)
  • HY-W027446R
    Pyridoxal hydrochloride (Standard) 65-22-5
    Pyridoxal hydrochloride (Standard) is the analytical standard of Pyridoxal hydrochloride. This product is intended for research and analytical applications. Pyridoxal hydrochloride, the hydrochloride form of Pyridoxal (HY-107469), is a newly developed neuroprotective agent. Pyridoxal hydrochloride is one of the major forms of vitamin B6. Pyridoxal hydrochloride is solvolyzed in methanol to form pyridoxal monomethylacetal. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine. Pyridoxal hydrochloride is proming for research of carpal tunnel syndrome (CTS).
    Pyridoxal hydrochloride (Standard)
  • HY-W030796R
    Lactisole free acid (Standard) 13794-15-5 98%
    Trifluoperazine (dihydrochloride) (Standard) is the analytical standard of Trifluoperazine (dihydrochloride). This product is intended for research and analytical applications. Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis.
    Lactisole free acid (Standard)
  • HY-W032013R
    1-Octanol (Standard) 111-87-5
    1-Octanol (Standard) is the analytical standard of 1-Octanol. This product is intended for research and analytical applications. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents. 1-Octanol is a highly attractive biofuel with diesel-like properties.
    1-Octanol (Standard)
  • HY-W038287R
    2-Methylbenzoxazole (Standard) 95-21-6 98%
    2-Methylbenzoxazole (Standard) is the analytical standard of 2-Methylbenzoxazole. This product is intended for research and analytical applications. 2-Methylbenzoxazole is an endogenous metabolite.
    2-Methylbenzoxazole (Standard)
  • HY-W039157R
    2-Acetyl-3-ethylpyrazine (Standard) 32974-92-8 98%
    2-Acetyl-3-ethylpyrazine (Standard) is the analytical standard of 2-Acetyl-3-ethylpyrazine. This product is intended for research and analytical applications. 2-Acetyl-3-ethylpyrazine is an endogenous metabolite.
    2-Acetyl-3-ethylpyrazine (Standard)
  • HY-W040040A
    γ-Cyclodextrin hydrate 91464-90-3 98%
    γ-Cyclodextrin hydrate is an orally active cyclic oligosaccharide composed of eight glucose molecules, which can be formed by bacteria digesting starch. γ-Cyclodextrin hydrate can form water-soluble inclusion complexes with a variety of poorly soluble compounds and is widely used in fields such as pharmacy and food. In addition, γ-Cyclodextrin hydrate has good safety.
    γ-Cyclodextrin hydrate
  • HY-W040040R
    γ-Cyclodextrin (Standard) 17465-86-0 98%
    γ-Cyclodextrin (Standard) is the analytical standard of γ-Cyclodextrin (HY-W040040). This product is intended for research and analytical applications. γ-Cyclodextrin is an orally active cyclic oligosaccharide composed of eight glucose molecules, which can be formed by bacteria digesting starch. γ-Cyclodextrin can form water-soluble inclusion complexes with a variety of poorly soluble compounds and is widely used in fields such as pharmacy and food. In addition, γ-Cyclodextrin has good safety.
    γ-Cyclodextrin (Standard)
  • HY-W040055A
    L-(-)-Neopterin 2277-43-2 98%
    L-(-)-Neopterin (L-erythro-Neopterin) is a cholinergic receptor that acts as a competitive antagonist, countering the inhibitory effects of pteridine diuretics on the growth of Crithidia fasciculata. L-(-)-Neopterin can be used in research related to the nervous system and purine metabolism.
    L-(-)-Neopterin
  • HY-W040240R
    L-(-)-Sorbose (Standard) 87-79-6
    (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one (Standard) is the analytical standard of (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. This product is intended for research and analytical applications. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite.
    L-(-)-Sorbose (Standard)
Cat. No. Product Name / Synonyms Application Reactivity